Anti-microbial coating innovations to prevent healthcare-associated infection

Commentary: Worldwide, millions of patients are affected annually by healthcare-associated infection (HCAI), impacting up to 80,000 patients in European Hospitals on any given day.[1] This represents not only public health risk, but also an economic burden. Through its Cooperation in Science and Technology programme (COST), the European Commission has recently funded a four-year initiative to establish a network of stakeholders involved in development, regulation and use of novel anti-microbial coatings for

Comparative performance of a panel of commercially available antimicrobial nanocoatings in Europe

Background Bacterial resistance against the classic antibiotics is posing an increasing challenge for the prevention and treatment of infections in health care environments. The introduction of antimicrobial nanocoatings with active ingredients provides alternative measures for active killing of microorganisms, through a preventive hygiene approach. Purpose The purpose of this study was to investigate the antimicrobial activity of a panel of antimicrobial coatings available on the

Mechanism of copper surface toxicity in Escherichia coli O157:H7 and Salmonella involves immediate membrane depolarisation followed by slower rate of DNA destruction which differs from that observed for Gram-positive bacteria

We have reported previously that copper I and II ionic species, and superoxide but not Fenton reaction generated hydroxyl radicals, are important in the killing mechanism of pathogenic enterococci on copper surfaces. In this new work we determined if the mechanism was the same in non-pathogenic ancestral (K12) and laboratory (DH5α) strains, and a pathogenic strain (O157), of Escherichia coli. The pathogenic strain exhibited prolonged

Minimum information about a biofilm experiment (MIABiE): standards for reporting experiments and data on sessile microbial communities living at interfaces

The minimum information about a biofilm experiment (MIABiE) initiative has arisen from the need to find an adequate and scientifically sound way to control the quality of the documentation accompanying the public deposition of biofilm-related data, particularly those obtained using high-throughput devices and techniques. Thereby, the MIABiE consortium has initiated the identification and organization of a set of modules containing the minimum information that needs

N-halamine copolymers for biocidal coatings

A vinyl N-halamine acrylamide monomer was copolymerized with silane-, epoxide-, and hydroxyl group-containing monomers. The resultant copolymers were coated onto cotton fabric through hydrolysis of alkoxy groups with formation of silyl ether bonding, opening of the epoxide ring and subsequent reaction with hydroxyl groups on cellulose, and by crosslinking between the hydroxyl groups on the copolymer and on cellulose, respectively. The coatings were rendered biocidal

A new way to find dielectric properties of liquid sample using the quartz crystal resonator (QCR)

The main objective of this article is to demonstrate by performing experimental measurements how the equivalent capacitance C0 changes when a fluid sample such as water is in contact with the crystal and to relate this change with the relative permittivity of the fluid. These measurements were compared with simulations of traditional models like Butterworth–Van Dyke (BVD). To obtain the change of C0 when the

Thermal and rheological characterization of antibacterial nanocomposites: Poly(amide) 6 and low-density poly(ethylene) filled with zinc oxide.

In this study, the filler–matrix interactions are assessed in two nanocomposites having different antibacterial activity. The two polymers used as matrix are poly(amide) 6 (PA6) and low-density poly(ethylene) (LDPE). The filler, zinc oxide (ZnO) nanoparticles, with a content as low as 1 w/w% in the polymers showed great antibacterial activity against Escherichia coli and Staphylococcus aureus. However, the bacterial slaying capability of composites was found

Antimicrobial sensitivity profile of Chlamydia trachomatis isolates from Croatia in McCoy cell culture system and comparison with the literature.

BACKGROUND: Chlamydia trachomatis (C. trachomatis) is the most common bacterial agent of sexually transmitted infections around the world, but susceptibility testing of this pathogen is rarely pursued due to its intracellular niche. The principal aims of this research were to determine in vitro sensitivity profile of urogenital chlamydial strains isolated from Croatian patients and to compare obtained concentration values of different antimicrobial drugs mutually and

45S5 Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity

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Postantibiotic effect of colistin alone and combined with vancomycin or meropenem against Acinetobacter spp. with well defined resistance mechanisms

Previous studies found short postantibiotic effect of colistin on Acinetobacter baumannii. Many studies have evaluated the potential for synergy between colistin and other antibiotics against A. baumannii. The aim of this study was to determine in vitro synergy and postantibiotic effect (PAE) of colistin alone and combined with other antibiotics (vancomycin or meropenem) against eight carbapenem-non-susceptible Acinetobacter spp. strains with defined resistance mechanisms. It was