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AMiCI Action in Relation to Existing Efforts at European Level

Pipette adding fluid to one of several test tubes
Pipette adding fluid to one of several test tubes

Coordination of the best European research resources and capabilities will form the necessary critical mass and develop the most advanced scientific approaches to tackle AMR, reversing its increasing trend, and leading to the sustainable use of antibiotics and treatments for infectious diseases. In this context, the networking efforts of AMICI provide an important link to the EC’s Joint Programming Initiative (JPI) on AMR. This connection will support the JPI in their definition, development and implementation of a common strategic research agenda that individual Member States are not capable of handling independently. The JPI on AMR will develop integrated approaches to pursue unique, world-class research on AMR that will be translated into new prevention and intervention strategies that improve the public health and the wellbeing of populations, and deliver economic and societal benefits throughout Europe and beyond. AMICI, as one of the networks bringing together different stakeholders and will contribute to an important element of the mission of the JPI AMR: to connect to and collaborate with the different stakeholders involved in its mission.

Some of the JPI AMR recommendations are pivotal to the AMICI Action. For example, development and implementation of interventions to prevent colonization, infection and transmission of resistant bacteria by hospitalised patients. Research on the effectiveness of intervention strategies and how they can most effectively be implemented is also required. Furthermore, political and societal awareness on the threat of AMR crucial to stimulate the implementation of measures to fight the misuse of antibiotics and to stimulate innovation. Knowledge transfer and intensive collaborations between scientists and policy makers is important for the successful adaptation or adoption of measures that have impact on reducing AMR, have social support and are cost effective.

Many efforts to reduce AMR have been initiated, are ongoing and have been concluded. However many of these have been proven to be only partially sufficient. In order to succeed, a holistic approach is needed (Communication from the Commission to the European Parliament and the Council – Action plan against the rising threats from Antimicrobial Resistance). AMR is a major European and global societal problem, involving many different sectors e.g. medicine, veterinary medicine, animal husbandry, agriculture, environment and trade. It cannot be tackled successfully through isolated, sectoral efforts. Food and direct contact with animals may serve as a vehicle for the transmission of AMR from animals to humans emphasizing the link between human and veterinary medicine in line with the “One Health” initiative. The fact that resistance may spread from
country to country when people and animals travel or when food, feed and other possible vehicles of AMR are traded, stresses the need for coordinated efforts across borders. The AMICI network addresses key actions as formulated by the EC, for a successful fight against AMR including the prevention of microbial infections and their spread through the sustainable introduction of AMC and new cleaning.

AMICI aims at being an innovative, out-of-the-box network that will challenge classic approaches in this field, such as new antibiotic development, thereby challenging older concepts and sectoral thinking and pave the way for innovative approaches, such as introduction of AMC and new cleaning. The participants, representing the entire value chain in healthcare, has the power to introduce new concepts into existing structures in hygiene, microbial resistance and cleaning-disinfection. AMICI has contacted other COST Actions, such as iPromedai, to explore how AMICI can benefit from the experiences and results with respect to combatting device-associated infections and the challenges they face in bringing together clinics, engineering, pharmacology and microbiology. But also to evaluate if and how the work from AMICI can feed into the iPromedai network. Similar efforts have been made with FP7 projects such as PARCIVAL, CuViTo, SelfClean and AMSCOPPER.

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